D-H Researchers Identify Simple Blood Test for Sepsis – Could Save Lives

LEBANON, NH – Sepsis kills a quarter of a million Americans each year – as many as stroke and Alzheimer’s combined – but very little has changed in the treatment of this age-old scourge. Now an international group of researchers including Dartmouth-Hitchcock Medical Center (D-H) may have identified a simple blood test that could identify patients at greatest risk of dying from sepsis, a condition that has long defied treatment. The discovery, published in Nature, could save thousands of lives each year.

For most people, the immune system is incredibly effective at dealing with minor injuries such as scrapes and cuts. The body is able to wall of and clear an infection. But, when that system fails, a local infection can spread throughout the bloodstream, creating the condition known as sepsis.  The body’s life-threatening reaction is known as septic shock and it can quickly kill the patient.  Numerous treatments attempt to save the patients by targeting the overzealous immune response, but they have been largely ineffective in saving lives.

Researchers may have determined how sustained inflammation from a sepsis infection can trigger immunoparalysis, a condition in which patients are at much higher risk of new infections because their immune system is not capable of responding to new threats. The research team, including Matthew S. Hayden M.D., Ph.D, a senior scientist in Dermatology at D-H, identified two tiny pieces of genetic code known as microRNAs (miR-221 and miR-222) that are produced in immune cells during prolonged inflammation.

“When cells of the immune system are exposed to bacterial products for long periods of time, they increase their expression of these two small RNAs, which target a part of the cellular machinery that is needed for the inflammatory response,” Hayden explains.   “As a result, when immune cells have high levels of these microRNAs, as they do in some sepsis patients, they are no longer effective at fighting off new infections.”

Testing for sepsis is not easy.  The problem has been pinpointing what is causing the massive infection and applying the right treatment without doing more harm to the patient. Many patients who survive this initial spread of infection remain at significant risk of death, partly because their immune system is almost paralyzed.

“The best treatment for sepsis starts with rapid detection. Our results suggest that specific molecules called microRNAs may be potential biomarkers of poor prognosis, indicating the need for more aggressive treatment options,” explains the study’s senior leader Sankar Ghosh, PhD, the chair of the Department of Microbiology & Immunology at Columbia University Vagelos College of Physicians and Surgeons.

The researchers have now shown that sepsis patients have higher levels of these microRNAs and are more likely to experience organ failure and immunosuppression.  A simple blood test looking for these tiny particles may help identify the highest-risk sepsis patients.  That could help identify therapies that help to reinvigorate the immune system by reversing immunoparalysis in order to prevent the secondary infections in sepsis patients.

Clinical trials will test the validity and usefulness of testing patients for these microRNAs as a quick guide to prognosis and treatment. The research comes at a time when the number of sepsis cases per year has been on the rise in the United States, according to the National Institute of Health. Creating better diagnostics may be able to help reverse this trend and save lives.

The study, published in Nature, is titled, “Induction of innate immune memory via microRNA targeting of chromatin remodelling factors.”

2018 NH Moose Permit Auction Now Open

CONCORD, NH — The Wildlife Heritage Foundation of New Hampshire announces the launch of the 2018 NH Moose Permit Auction, its primary fundraiser to support the programs of the NH Fish and Game Department. Official bid guidelines and documents can be downloaded from the Foundation’s website at www.nhwildlifeheritage.org or by calling (603) 496-2778. Sealed bids are due by August 10, 2018.

This year marks the tenth annual auction run by the Wildlife Heritage Foundation of New Hampshire. The Foundation is authorized to auction only one permit this year, in line with statewide moose population goals. The highest bidder in the auction will receive a 2018 New Hampshire moose hunt permit, as well as a 2018 New Hampshire general hunting license. Last year, the auction garnered bids from three states, with a winning bid from Massachusetts of $20,999.99.

Foundation Chair Deborah Coffin states, “The Foundation relies on the moose permit auction to provide funding to support programs at NH Fish and Game. Programs such as wildlife conservation and education are essential for the education of our youngsters, who are the future stewards of the natural environment in our great state.”

The successful bidder in the 2018 auction will be able to harvest one moose of either sex in most Wildlife Management Units. The exceptions are Units H2N, H2S and K where permit issuance has been suspended. Individuals who receive a permit in the 2018 New Hampshire open moose hunt lottery will not be eligible to participate in the auction. Additional information on moose hunting in New Hampshire, including rules, permits, and licenses can be found at www.huntnh.com/hunting/moose.html.

Proceeds from the auction help support critical fish and wildlife conservation initiatives, along with education programs of the Department, such as freshwater angler surveys, fish hatchery improvements, deer decoy replacements, lynx camera studies, boardwalk replacement at Great Bay Discovery Center, and landowner access programs.

Since its establishment in 2006, the Wildlife Foundation of New Hampshire has awarded over 100 grants to NH Fish and Game projects, as well as sponsoring multiple years of Discover Wild NH Day.

To learn more about the Foundation and how you can help preserve New Hampshire’s outdoor gifts, visit www.nhwildlifeheritage.org or visit on Facebook at www.facebook.com/wildlifeheritagenh.

White River Junction Man Arrested After Pursuit

Lebanon NH – On July 9, 2018 at approximately 6:40PM the Lebanon Police Department received a report of a vehicle operating erratically, with a further report that the operator didn’t appear to be fully conscious.
Lebanon Police Corporal Garrett Hubert and Officer James Pike located the vehicle stopped on Mechanic Street after it had struck a telephone pole. As officers prepared to approach the vehicle, the driver fled on Mechanic Street toward downtown. Lebanon Police Officers pursued the vehicle, observing that it was operating in an extremely erratic and dangerous manner, at speeds of no more than 25 MPH.

The driver eventually stopped on School Street, where he was ordered from the vehicle and taken into custody. Norman Bevins, age 44, of White River Junction, Vermont is charged with Disobeying an Officer, a Class A Misdemeanor, Driving While Intoxicated, a Class B Misdemeanor, and a Violation offense of Open Container. At arraignment, Bevins will also be facing a charge of Reckless Operation, a Violation.

Bevins is currently on probation and he was held at the Grafton County House of Corrections pending the filing of a probation violation.
Bevins will be arraigned in the New Hampshire 2nd Circuit Lebanon District Division on July 10, 2018

Lebanon Police to Hold “Coffee with a Cop” Event at The Fort

On July 24th, officers from the Lebanon Police Department and community members will come together in an informal, neutral space to discuss community issues, build relationships, and drink coffee.
All community members are invited to attend. The event begins at 8:00am on Tuesday, July 24th at The Fort Exit 18, 151 Heater Rd, Lebanon. Please contact Captain Tim Cohen with questions: (603) 448-8800 or tim.cohen@lebanonnh.gov.
Coffee with a Cop provides a unique opportunity for community members to ask questions and learn more about the department’s work in Lebanon’s neighborhoods.
The majority of contacts law enforcement has with the public happen during emergencies, or emotional situations. Those situations are not always the most effective times for relationship building with the community and some community members may feel that officers are unapproachable on the street. Coffee with a Cop breaks down barriers and allows for a relaxed, one-on-one interaction.
Coffee with a Cop is a national initiative supported by The United States Department of Justice, Office of Community Oriented Policing Services. Similar events are being held across the county, as local police departments strive to make lasting connections with the communities they serve.
The program aims to advance the practice of community policing through improving relationships between police officers and community members one cup of coffee at a time.

West Lebanon Fire Leaves Three Families Homeless

West Lebanon NH – On July 4, 2018, West Lebanon, NH: At 2203 hours the Lebanon Fire Department was dispatched to the 4 Butternut Lane, Butternut Apartments for an automatic fire alarm. Prior to responding Lebanon Communications received additional information via 911 reporting smoke coming from an apartment on the 2nd floor. Upon arrival of Lebanon Truck 2 from the West Lebanon Station at 2208 hours, Lt. Zachary Bryan reported heavy smoke visible from a 2nd floor apartment with numerous occupants evacuated. Truck 2 personnel advanced a hose line and quickly contained the fire to a bathroom in Apartment I and performed a primary search for occupants. Additional personnel arrived on scene from Lebanon, Hanover and Hartford, VT and assisted with a search of several apartments. During the search several cats were located and two were given oxygen by fire personnel and transported to SAVES Animal Hospital by a bystander. There was some minor fire extension into the apartment directly above the fire and several others suffered smoke and water damage.
The fire was declared under control at 2230 hours and there were no injuries. Three apartments were deemed unsafe for occupancy and displaced 5 adults and 4 children. The VT/NH Chapter of the American Red Cross assisted the displaced with temporary housing.
The cause of the fire is under investigation and not considered suspicious.
Lebanon units cleared the scene and turned the property over to property management at 0051 hours.
Please contact Chief Christopoulos at the Lebanon Fire Department should you have any questions at (603) 448-8810.

Man Armed With Knife Charged With Criminal Threatening After Brief Stand-Off

Lebanon NH – On July 04, 2018 at approximately 12:50PM, the Lebanon Police Department received a call that a male subject had threatened several people with a knife in the area of the Granite Street and West Street intersection. Responding officers determined the male suspect had entered an apartment at 17 West Street. They shut down the roadway and secured the perimeter of that address.
Investigating officers determined the armed suspect was James E. Wallace, age 33, of 17 West Street, and that he had threatened several people with a large knife after a car had turned around in his driveway. Officers attempted to make contact with Wallace but he refused to come to the door.
Officers from the Lebanon Police Department Tactical and Containment Team, along with officers from the Patrol Bureau, continued trying to make contact with Wallace. Tactical Officers deployed the department’s armored vehicle and through use of the Public-Address system, successfully encouraged Wallace to exit the residence. He was then taken into custody without further incident.
Wallace is charged with Criminal Threatening with a Deadly Weapon, a Class B Felony.
Wallace was held on $15,000 Cash Bail and was transported to the Grafton County House of Corrections pending arraignment on July 5, 2018 in the Grafton County Superior Court

Update Lebanon Police Officers Assist Injured Bald Eagle

On June 30, 2018, Officer Jeremy Perkins was alerted of an injured Bald Eagle by a local juvenile. Officer Perkins located the Eagle in area of Plainfield Road and Trues Brook Road.

On June 30, 2018, Officers Perkins was alerted of an injured bald eagle by a local
juvenile. Officer Perkins located the Eagle in area of Plainfield Road and Trues
Brook Road, and he and Officer Gaspard kept the Eagle out of traffic until VINS
(Vermont Institute of Natural Science) arrived to safely capture it, in hopes of
VINS assessed the eagle’s multiple injuries and unfortunately found that they were
too severe, and the eagle had to be humanely euthanized. What caused the injuries is unclear.
Thank you to the juvenile who reported the injured eagle, VINS, and all who came
together to try to save the eagle

Lebanon Police Officers Assist Injured Bald Eagle

On June 30, 2018, Officer Jeremy Perkins was alerted of an injured Bald Eagle by a local juvenile. Officer Perkins located the Eagle in area of Plainfield Road and Trues Brook Road.

Officer Perkins and Officer Daniel Gaspard contained the bird and kept it from going into Route 12-A traffic. Officer Gaspard called VINS (Vermont Institute of Natural Science), who promptly responded to the scene and safely captured the Eagle. They plan to assess the Eagle’s injuries and hope to rehabilitate it.

Three Taken to Hospital after I-91 Crash in Norwich VT

Norwich VT – On 06/28/18 at approximately 1556 hours, this two car vehicle crash occurred on Interstate 91 at approximately mile marker 79/80, in the Town of Norwich, VT.  Operator Mark Bishop was traveling south on Interstate 91 when he allegedly swerved to avoid a slow or stopped vehicle in the roadway.  Bishop lost control of his vehicle, traveled across the center median and collided with Operator Richard Manivanh’s vehicle, which was traveling north on Interstate 91.  Both vehicles traveled off the eastern side of Interstate 91 before coming to rest.  Bishop vehicle sustained substantial front end damage and Bishop received minor injuries.  Manivanh and his two passengers, Chaya Patel of Hanover NH and Brian North of Lebanon NH had to be extricated from the vehicle and received moderate injuries.  All three were transported and are being treated at Dartmouth Hitchcock Medical Center.  This case remains under investigation

Fatal Accident on I-91 in Hartland VT

Hartland VT – On 06-28-2018 at 07:33am Vermont State Police responded to the report of a two car motor vehicle crash on Interstate 91 in the Town of Hartland. The crash occurred in the area of mile marker 60 north bound near Exit 9. Investigation revealed that the 2008 Chevy truck being operated by Joshua Rondeau of Springfield, VT lost control while traveling south bound, crossed the median and struck the 2007 Toyota Matrix head on. The operator of the Matrix was pronounced dead at the scene. A juvenile passenger in the Matrix sustained non-life threatening injuries and was transported to Dartmouth Hitchcock Medical Center. The operator of the Chevy truck and two juvenile occupants were also transported to DHMC with non-life threatening injuries. I91 north bound was closed for a period of time at exit 9 while crash investigators completed their on scene investigation. It was reopened at approximately 1:00PM.

The name of the deceased is being withheld until notification of family.